Due to payment processor restrictions we can no longer offer CBD online. You can still order CBD by contacting us directly. Email or call 614-262-7087.
Here are the brands we carry - CVsciences, Theramu and Koi CBD. We have all formulations available - capsules, gelcaps, topical balms and vape liquids.
What is Cannabidiol (CBD)?
What is Cannabidiol?
"Cannabinoids are a class of chemical compounds that act on specialized cellular receptors in both animals and humans. Cannabinoids originating from plants are called phytocannabinoids. The two most researched thus far are delta-9-tetrahydrocannabinol (THC), the psychoactive compound of cannabis and cannabidiol (CBD). There are currently 85 different cannabinoids isolated from the cannabis sativa species including hemp and marijuana. The hemp plant has significantly more CBD compared to marijuana, with CBD representing up to 40% of the total cannabinoids in this plant. 3
Hemp, unlike marijuana, is the major plant commercial source for CBD extracts. CBD is produced by the hemp plant in the form of a sticky resin produced in specialized glands located on young leaves, twigs and buds of the plant. The CBD-containing resin is a source of antioxidant, anti-inflammatory and numerous other protective molecules (that will be discussed) for the growth and reproductive functions of the plant.7 Extracts obtained from hemp's resin are used to make concentrated CBD produced and sold as a legal non-psychoactive nutritional supplement.”(Nutritional & Medical Applications for Cannabidiol: Hemp Health Benefits without THC R)
CBD's Many Health Benefits;
Anti-inflammatory
CBD receptors in the body regulate inflammation in the body and studies on CBD show that it is has potent anti-inflammatory properties;
"Anti-inflammatory effect is several hundred times more potent than aspirin when measured in standard animal tests and isolated cell assays;"(Nutritional & Medical Applications for Cannabidiol: Hemp Health Benefits without THC R)
"A 2012 study published in the Journal of Experimental Medicine found that CBD significantly suppressed chronic inflammatory and neuropathic pain in rodents"(R)
Anti-epileptic/Anticonvulsive/Antiseizure
The use of cannabis for epilepsy goes back to 1881. Here is a quote from the 1881 book "Epilepsy and other chronic convulsive diseases : their causes, symptoms, & treatment"
"Ext. cannabis indica (was administered) three times a day, was then ordered ; the fits ceased at once,
' a wonderful change ' the patient declared. He had no fit for six months, and then, having discontinued attendance, the fits recurred, but were at once arrested by the same dose of Indian hemp. He continued free from fits for some months, until, during my absence, bromide was substituted for the Indian hemp : the fits immediately recurred, and he left off treatment. He returned to the hospital in six months' time, and on Indian hemp passed two months without an attack."(R)
"Human studies have been equivocal:
In a double-blind study Cunha et al (1980) evaluated CBD for intractable epilepsy in 16 grand-mal patients. Each patient received 200 to 300 mg daily of CBD or placebo along with antiepileptic drugs continued up to 4-months. In the treatment group 7 of 8 responded with fewer seizures. In the placebo group 1 of 8 responded with fewer seizures
In a human study of intractable epilepsy with 12 subjects, Ames et al (19862 14 were unable to duplicate these results and participants showed no response to CBD
In 2012, in a review of 3 studies that exclusively used CBD for intractable seizures, Hill et al found that wo of the three demonstrated significant anti-seizure effects
In 2014 Insys Therapeutics (USA) was granted orphan drug designation for its pharmaceutical CBD for the treatment of glioblastoma multiforme (GBM) and two rare forms of epilepsy, Lennox-Gastaut Syndrome and Dravet Syndrome. GW Pharmaceuticals has also been given the same designation for a CBD drug for Dravet Syndrome in children.
Neuroprotective10,32
In experimental models activation of CB2 receptors (the receptors primarily associated with CBD) CBD has delayed progression of neurodegenerative events, in particular, those related to the toxic influence of microglial cells (excessive immune response) on neuronal homeostasis33. "
Neuroprotective-Protects the brain from concussion damage
Studies have shown CBD to both protect the brain from damage if given before a concussion and also to speed healing after a concusion. The Pittburg Steelers are now using CBD to help protect their players from concusions.
One of the main causes of brain damage after a concusion is caused by inflammation. CBD's anti-inflammatory properties help protect the brain from the damage caused by this inflammation. A study in Current Pharmaceutical Design showed
"Cannabinoids of all classes have the ability to protect neurons from a variety of insults that are believed to underlie delayed neuronal death after traumatic brain injury (TBI), including excitotoxicity, calcium influx, free radical formation and neuroinflammation."(R)
Dr Joseph Maroon the neuroseurgeon for the Pittburg Steelers is using CBD to protect the players from brain injury. He wrote the report "Nutritional & Medical Applications for Cannabidiol: Hemp Health Benefits without THC", in it he discusses the neuroprotective effects of cannibidiol;
"In experimental models activation of CB2 receptors (the receptors primarily associated with CBD) CBD has delayed progression of neurodegenerative events, in particular, those related to the toxic influence of microglial cells (excessive immune response) on neuronal homeostasis.
CBD has been shown to reduce glutamate toxicity of the brain.
CBD can reduce oxidative damage from glutamate via antioxidant effects
Neuroprotective benefits of CBD are reported to be greater than those of vitamin C and vitamin E. "
Anti-Cancer
Cannabinoids including CBD offer potential applications as antitumor drugs, based on the ability to limit inflammation, cell proliferation, and cell survival;
In particular, emerging evidence suggests that agonists of cannabinoid receptors expressed by tumor cells may offer a novel strategy to treat cancer;
GW Pharmaceuticals (UK) has preclinical data and has been approved for a human trial for GBM using submaximal doses of THC and CBD along with temozolomide (TMZ). This pharmaceutical THC and CBD has produced a strong antitumoral action in both TMZsensitive and TMZ-resistant tumors, and will be therapeutically exploited for the management of GBM. 38
Here is paper which goes over the anti-cancer effects of CBD on various forms of cancer https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3579246/
Antioxidant
In a study 7 of 8 patients given CBD had fewer siezures
"In a double-blind study Cunha et al (1980) evaluated CBD for intractable epilepsy in 16 grand-mal patients. Each patient received 200 to 300 mg daily of CBD or placebo along with antiepileptic drugs continued up to 4-months. In the treatment group 7 of 8 responded with fewer seizures. In the placebo group 1 of 8 responded with fewer seizures "
“In the 1970's CBD's anticonvulsive effects in humans were discovered. Later, other studies have shown anti-nausea, anti-anxiety, antioxidant, anti-inflammatory and analgesic effects as well as other disease specific benefits. “(R)
Helps in reducing marijuana use
Extracts from interview with Stuart Tomc from CV Sciences "Stuart Tomc, Cannabinoid Educator: Staying in Step With
the State of Research";
“We have 2 primary endocannabinoid receptors and they are known as cannabinoid receptors 1 and 2, or CB1 and CB2. These are G protein–coupled receptors and they are located in the central and the peripheral nervous system; white blood cells; adipocytes, or fat cells; the liver; and bone. These receptor sites—and this whole system—are involved in learning and synaptic plasticity, immune regulation, appetite and pain, metabolic health and insulin sensitivity, and myriad other things.”
“The low-hanging fruit(health benefits from CBD) is really in pain, inflammation, anxiety, and neuroprotection. Those are areas where there is great interest—also in post-traumatic stress disorder.”
Summary of the Actions of CBD
CBD has been studied and found in both in vivo and in vitro studies to exert anti-inflammatory, analgesic, anti-nausea, anti-emetic, anti-psychotic, anti-ischemic, anxiolytic and anti-epileptic actions that may offer significant human health benefits.
Anti-inflammatory
CBD — analgesic and anti-inflammatory effect mediated by dual COX and LOX Inhibition; Anti-inflammatory effect is several hundred times more potent than aspirin when measured in standard animal tests and isolated cell assays;
CBD, like THC, also stimulates the release of prostaglandin E2 (anti-inflammatory) from synovial cells and, like THC, inhibits leukotriene B4 synthesis in human WBCs;
Topical CBD Cream shown to reduce acne by reducing sebum overproduction, unwanted sebocyte proliferation and inflammation.
Analgesic Effects
Modulates immune response — anti-inflammatory and reduces WBC-mediated cytokine action;
Blocks peripheral nerve fibers — used for multiple sclerosis spasticity and associated neuropathic pain;
CBD, unlike morphine, effective at relieving chemotherapy-induced neuropathic pain with no psycho-active effects.
Anti-nausea, Anti-emetic & Gastrointestinal Benefits
Direct action on gut smooth muscle;
Inhibits acetylcholine induced contractions in the isolated mouse ileum;
Effective to suppress nausea and vomiting;
Anti-proliferative actions in human colorectal carcinoma;
Prevents oxidative stress intestinal epithelial cells. Anxiolytic.
Animal models and healthy human volunteers, demonstrate anxiolytic-like effects of CBD;
CBD reduces anxiety in clinical patients with social anxiety disorder;
Countered THC-induced anxiety effects.
Anti-epileptic
Human studies have been equivocal:
In a double-blind study Cunha et al (1980) evaluated CBD for intractable epilepsy in 16 grand-mal patients. Each patient received 200 to 300 mg daily of CBD or placebo along with antiepileptic drugs continued up to 4-months. In the treatment group 7 of 8 responded with fewer seizures. In the placebo group 1 of 8 responded with fewer seizures
In a human study of intractable epilepsy with 12 subjects, Ames et al (19862 14 were unable to duplicate these results and participants showed no response to CBD
In 2012, in a review of 3 studies that exclusively used CBD for intractable seizures, Hill et al found that wo of the three demonstrated significant anti-seizure effects
In 2014 Insys Therapeutics (USA) was granted orphan drug designation for its pharmaceutical CBD for the treatment of glioblastoma multiforme (GBM) and two rare forms of epilepsy, Lennox-Gastaut Syndrome and Dravet Syndrome. GW Pharmaceuticals has also been given the same designation for a CBD drug for Dravet Syndrome in children.
Neuroprotective
In experimental models activation of CB2 receptors (the receptors primarily associated with CBD) CBD has delayed progression of neurodegenerative events, in particular, those related to the toxic influence of microglial cells (excessive immune response) on neuronal homeostasis.
CBD has been shown to reduce glutamate toxicity of the brain.
CBD can reduce oxidative damage from glutamate via antioxidant effects
Neuroprotective benefits of CBD are reported to be greater than those of vitamin C and vitamin E.
Anti-cancer
Cannabinoids including CBD offer potential applications as antitumor drugs, based on the ability to limit inflammation, cell proliferation, and cell survival;
In particular, emerging evidence suggests that agonists of cannabinoid receptors expressed by tumor cells may offer a novel strategy to treat cancer;
GW Pharmaceuticals (UK) has preclinical data and has been approved for a human trial for GBM using submaximal doses of THC and CBD along with temozolomide (TMZ). This pharmaceutical THC and CBD has produced a strong antitumoral action in both TMZsensitive and TMZ-resistant tumors, and will be therapeutically exploited for the management of GBM. 38 (Nutritional & Medical Applications for Cannabidiol: Hemp Health Benefits without THC R)
*Not intended to treat or cure any disease
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